Dr Martin Hibberd BSc(Hons) PhD; Senior Group Leader, Infectious Diseases at the Genome Institute of Singapore and has adjunct positions at the National University of Singapore and Imperial College (London, UK). Graduated with Honors from Brunel University in 1985 (West London, UK) and received his Doctorate, on the immune-genetics of the human T-cell antigen receptor, from King’s College, London. Has a broad scientific background spanning both microbial and human determinants of infectious and inflammatory diseases. Previous posts include WHO-funded Senior Microbiologist at the UK’s central Public Health Laboratories, and for seven years prior to his current appointment he was Lecturer and Senior Lecturer in Pediatric Infectious Diseases at the Imperial College School of Medicine, one of the very top-ranking British universities. Current research interests cover both pathogen and host aspects of infectious disease, understanding how microbial agents causes the observed disease (including pathogen identification and sequence characterization) and why specific individuals are susceptible to the disease (using host genetics on a genomic scale). Approaching infectious disease from these two directions also allows specific host pathogen responses to be investigated (utilizing RNA micro and low density arrays). This work aims to identify key host responses to specific pathogens that could be targeted by new therapies.
Selected Recent Publications (from more than 60 in total)
Vernon J Lee, Jonathan Yap, Alex Cook, Mark I Chen, Joshua Tay, Boon Huan Tan, Jin Phang Loh, Seok Wei Chew, Wee Hong Koh, Raymond Lin, Lin Cui, Charlie Lee, Wing-Kin Sung, Christopher W Wong, Martin L Hibberd, Wee Lee Kang, Benjamin Seet, Paul A Tambyah. Oseltamivir ring prophylaxis for containment of Influenza A (H1N1-2009) outbreaks. New England Journal of Medicine (In press).
Kim-Sung Lee, Yee-Ling Lai, Sharon Lo, Timothy Barkham, Pauline Aw, Peng-Lim Ooi, Ji-Choong Tai, M. L Hibberd, Patrik Johansson, Seow-Poh Khoo, Lee-Ching Ng. Surveillance of dengue viruses in Singapore warns of dengue serotype 2 outbreak and reveals multiple importations of dengue serotype 3. Emerging Infect Disease (In press).
Peng Lim Ooi, Florence YL Lai, Chew Ling Low, Raymond Lin, Christopher Wong, Martin Hibberd, Paul Ananth Tambyah. Clinical and Molecular Evidence for Transmission of novel Influenza A (H1N1-2009) on a commercial airplane. Archives of Internal Medicine (In press)
Horby P, Sudoyo H, Viprakasit V, Fox A, Thai PQ, Yu H, Davila S, Hibberd M, Dunstan SJ, MonteeraratY, Farrar JJ, Marzuki S, Hien NT. What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1? Epidemiol Infect. 2010 Mar 18:1-9.
Lee CW, Koh CW, Chan YS, Aw PP, Loh KH, Han BL, Thien PL, Nai GY, Hibberd ML, Wong CW, Sung WK. Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays. Nucleic Acids Res. 2010 Feb 25.
Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Rong-De Yang, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ. Genomewide Association Study of Leprosy.N Engl J Med. 2009 Dec 16.
Schreiber MJ, Holmes EC, Ong SH, Soh HS, Liu W, Tanner L, Aw PP, Tan HC, Ng LC, Leo YS, Low JG, Ong A, Ooi EE, Vasudevan SG, Hibberd ML. Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore. J Virol. 2009 May;83(9):4163-73.
Hibberd ML*, Long HT*, Hien TT, Dung NM, Ngoc TV, Farrar J, Wills B, Simmons CP. Patterns of Gene Transcript Abundance in the Blood of Children with Severe or Uncomplicated Dengue Highlight Differences in Disease Evolution and Host Response to Dengue Infection. J Infect Dis. 2009 Jan 12.
Umareddy I, Tang KF, Vasudevan SG, Devi S, Gu F* Hibberd ML*. Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. J Gen Virol. 2008 Dec;89(Pt 12):3052-62.
Hartman AL, Ling L, Nichol ST, Hibberd ML. Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein. J Virol. 2008 Jun;82(11):5348-58.
Lundin A, Bok CM, Aronsson L, Björkholm B, Gustafsson JA, Pott S, Arulampalam V, Hibberd M, Rafter J, Pettersson S. Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol. 2008 May;10(5):1093-103.
Tanner L, Schreiber M, Low JG, Ong A, Tolfvenstam T, Lai YL, Ng LC, Leo YS, Thi Puong L, Vasudevan SG, Simmons CP, Hibberd ML, Ooi EE. Decision tree algorithms predict the diagnosis and outcome of dengue Fever in the early phase of illness. PLoS Negl Trop Dis. 2008 Mar 12;2(3):e196.
Ong SH, Yip JT, Chen YL, Liu W, Harun S, Lystiyaningsih E, Heriyanto B, Beckett CG, Mitchell WP, Hibberd ML, Suwandono A, Vasudevan SG, Schreiber MJ. Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic. Infect Genet Evol. 2008 Mar;8(2):191-204.
Fink J, Gu F, Ling L, Tolfvenstam T, Olfat F, Chin KC, Aw P, George J, Kuznetsov VA, Schreiber M, Vasudevan SG, Hibberd ML. Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis. 2007 Nov 21;1(2):e86.
Wong CW, Heng CL, Wan Yee L, Soh SW, Kartasasmita CB, Simoes EA, Hibberd ML, Sung WK, Miller LD. Optimization and clinical validation of a pathogen detection microarray.Genome Biol. 2007;8(5):R93.
Zhang T, Breitbart M, Lee WH, Run JQ, Wei CL, Soh SW, Hibberd ML, Liu ET, Rohwer F, Ruan Y. RNA Viral Community in the Human Gut: Prevalence of plant pathogenic viruses. PLoS biology 2006; 4(1):e3.
Liu J, Lim SL, Ruan Y, Ling AE, Ng LF, Drosten C, Liu ET, Stanton LW, Hibberd ML. SARS transmission pattern in Singapore reassessed by viral sequence variation analysis. PLoS Med. 2005 Feb;2(2):e43.
