Prof Jean-Louis Guéant

Inserm U954, Medical Faculty of Nancy
Chief Department of Biochemistry-Molecular Biology-Nutrition-Metabolism, University Hospital Center of Nancy, France

Email: jean-louis.gueant@medecine.uhp-nancy.fr

Dr Guéant, MD, DSc, AGAF, is the scientific deputy dean and the director of Inserm U954 « Nutrition-Genetics and Environmental Exposure » at the Medical Faculty of Nancy, Nancy-University, France. He is deputy president of the Inserm scientific committee of Cardiovascular-Nutrition-Metabolism and president of the French Universitary Association of Medical Biochemistry and Molecular Biology. His field of interest is the one-carbon metabolism in nutrigenetics and nutrigenomics. He coordinates the program « Nutrivigene » of the French national agency for research. The Inserm Research Unit 954 aims to evaluate short and long term effects of deficiency in methyl donors/precursors in relation with perinatology, fetal programming, inherited metabolic rare diseases and aging. Its field of interest is focused on the links between the one-carbon metabolism and epigenetic mechanisms involved in cellular stress, inflammation, genotoxicity and immunomodulation, in brain, heart, and digestive organs. The project is designed with a transversal approach, using relevant cellular and animal models and validating the experimental pathomechanisms in population studies. A national reference centre of inherited metabolic diseases is led by the investigators of the Unit, in the University Hospital Center of Nancy.