Dr Valere Cacheux-Rataboul

Dr Valere CACHEUX, PharmD, PhD
Principal Investigator
Genome Institute of Singapore


Email: cacheuxrv@gis.a-star.edu.sg

Our team has for objectives to identify and characterize the genomic architecture of chromosomal rearrangements in genomes. In cancer genomes these rearrangements can lead to fusion genes and could be used as markers in tumor screening. Then, chromosomal anomalies associated with congenital disorders can aid the identification of new genetic syndromes. Using known technologies such as FISH and microarrays in combination with DNA-PET technology, we can also precisely identify all the breakpoints of chromosomal anomalies and understand the genomic organization of such rearrangements. With the precise description of the breakpoints, a second focus is to understand why these rearrangements occur in cancer genomes and in associated diseases rearrangements.